Soapberry Extract CAS 223748-41-2

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1. Anti-tumor effect: Research by Japanese scholar Nagao Tsuneaki found that the methanol solution of soapberry extract has an inhibitory effect on the proliferation of B16F10 (mouse melanoma), HeLa, and MK-1 (human gastric cancer) cells, and the active part is concentrated Of the monosaponin components, the disaponin component is completely inactive. Research by HUANG et al. also shows that soapberry monosaponins are cytotoxic to certain human tumor cells. 2. Antihypertensive effect: Research by Wang Weisheng and others found that soapberry saponins have antihypertensive effects on rats with renal hypertension, and can reduce angiotensin II and endothelin and increase nitric oxide. Research by Long Zijiang and others has also shown that soapberry saponins have antihypertensive effects on rats with essential hypertension, and its mechanism of action may be related to changes in the renin-angiotensin system and vascular endothelial function. 3. Antibacterial effect: British scholar TAMURA et al. studied the antidermal fungal activity and structure-activity relationship of saponins in soapberry peel, and found that the saponin mixture (including single chain and chemical book) after mixing 70% and 85% methanol eluent Double-chain glycosides (SP-mix) have significant antidermal fungal effects, among which single-chain glycosides have the strongest inhibitory effect. In addition, SP-mix has a strong inhibitory effect on yeast, and is ineffective against general fungi except Trichomycetes. SP-mix has a moderate inhibitory effect on Gram-positive bacteria and is ineffective against Gram-negative bacteria. Fu Yong et al. used Candida albicans experiments to prove that the 70% ethanol eluate of soapberry extract was also enriched in antibacterial active parts. 4. Anti-inflammatory effect: Anti-ulcer MEYER and other experiments have proven that oral soapberry extract has anti-inflammatory and anti-ulcer effects. IBRAHIM et al. also reported that soapberry ethanol extract has a significant inhibitory effect on Helicobacter pylori both in vivo and in vitro, and does not produce drug resistance. 5. Other pharmacological effects: Sapindus saponin also has liver protection, myocardial ischemia protection, anti-thrombosis, spermicidal and other effects. Therefore, soapberry extract has great potential value in the development and treatment of tumors, cardiovascular diseases, skin diseases, ulcers, etc.